Endocrine Abstracts

Aim: Triple-A Syndrome (TAS) is a rare autosomal recessive disorder characterized by three cardinal symptoms: alacrimia, achalasia and adrenal insufficiency due to ACTH insensitivity. The disease is caused by mutation in the AAAS gene on chromosome 12q13. Mutations in AAAS were identified in more than 90% of individuals and families with TAS. The aim of this study is to discuss the clinical, laboratory and molecular genetic analysis results of 5 patients with TAS.<p class=...

Subacute thyroiditis is a painful disease of the thyroid gland characterized with granulomatous inflammation. Adalimumab is a human monoclonal anti TNF antibody used in the treatment of several autoimmune diseases. Here we report a case of subacute thyroiditis associated with adalimumab treatment for ankylosing spondylitis. A 42 year old female patient was admitted to the hospital for fever, chills and neck pain radiating to the right ear. She was diagnosed with ankylosing spo...

Insulinomas are rare neuroendocrine tumors (NETs) of the pancreas with an incidence of four per 1 million persons per year. The co-existence of diabetes mellitus (DM) and insulinoma is very rare. We report a case of 73 year old women with malignant insulinoma and type 2 DM. A 73 year old woman with type 2 diabetes was referred to our clinic for recurrent and severe hypoglycemia especially in the early morning hours. The patient had a history of type 2 DM for 10 years. Although...